Pediatric Cancer Genome Project | Explore - St. Jude Children's Research Hospital, Washington University School of Medicine in St. Louis

A total of 600 diagnostic and 600 germline samples are planned.

ETV (46, 7.67)	7.67	46
MB (38, 6.34)	6.34	38
EPD (22, 3.67)	3.67	22
INF (22, 3.67)	3.67	22
HYPO (20, 3.34)	3.34	20
OS (19, 3.17)	3.17	19
CBF (17, 2.84)	2.84	17
LGG (16, 2.67)	2.67	16
RHB (13, 2.17)	2.17	13
PHALL (9, 1.5)	1.5	9
ACT (8, 1.34)	1.34	8
AMLM7 (4, 0.67)	0.67	4

LGG (27, 4.5)	4.5	27
HGG (21, 3.5)	3.5	21
EPD (18, 3.0)	3.0	18
PHALL (12, 2.0)	2.0	12
ERG (7, 1.17)	1.17	7
ETV (4, 0.67)	0.67	4
INF (2, 0.34)	0.34	2

In Pipeline~(200, 33.33%)	200
Sequence~In Progress~(91, 15.17%)	91
Sequence~and Analysis~Completed~(234, 39.00%)	234
Public~(59, 9.83%)	59
Published~(16, 2.67%)	16

	200
	91
	234
	59
~~RB (4, 0.67%)	4
T-ALL (12, 2.00%)	12

	200
	91
	234
NBL~(43, 7.17%)	43
HGG~(16, 2.67%)	16
	16

	200
	91
MB (38, 6.33)	38
LGG (16, 2.67)	16
INF (22, 3.67)	22
HYPO (20, 3.33)	20
ETV (46, 7.67)	46
PHALL (9, 1.50)	9
RHB (13, 2.17)	13
OS (19, 3.17)	19
EPD (22, 3.67)	22
AMLM7 (4, 0.67)	4
CBF (17, 2.83)	17
ACT (8, 1.33)	8
	59
	16

	200
ERG (7, 1.17%)	7
PHALL (12, 2.00%)	12
INF (2, 0.33%)	3
HGG (21, 3.50%)	21
ETV (4, 0.67%)	4
LGG (27, 4.50%)	27
EPD (18, 3.00%)	18
	234
	59
	16

Click on Disease(s) diplayed under Published section to see the associated data

Click on the Thumbnail image to pause the slide.

Protein Paint

The Protein Paint displays domains from the GenBank database and allows visualization of mutations and their locations within the protein of interest.

Protein Structure

If a 3D structure exists, a model is displayed, which actively encourages users to evaluate the general location, surrounding environment, and potential loss of interactions from a missense mutation. A user has the ability to manipulate the molecule through the website or download the structure file to their local computer.

PCGP Germline Variant Search

This tool enables you to search for chromosomes for SNPs at specific positions within PCGP patients.

Matrix Plot

The Matrix Plot enables you to visualize genomic alterations and the pathways in which they are found.

Coverage Plot

The Coverage Plot displays the distributions of genomic coverage (excluding sequencing gaps) across all chromosomes, comparing the matched germline and disease samples.

Genomic Alterations Summary

The Genomic Alterations Summary depicts copy number variations, single nucleotide variations, structural variations, and gene expressions for all patients with a specified disease.

Circos Plot

The Circos Plot depicts a comprehensive overview of a genome showing chromosomal rearrangements, copy number changes, loss-of-heterozygosity, SNVs, INDELs, and gene fusions.

Disease	WGS Discovery Cohort	Recurrence Cohort	Publication(s)
ETP Acute Lymphoblastic Leukemia	12 ETP	52 ETP 41 non-ETP	Wang J, et al. ; CREST maps somatic structural... Zhang J, et al. ; The genetic basis of...
Retinoblastoma	4	4	Zhang J, et al. ; A novel retinoblastoma therapy...
Neuroblastoma			Cheung NK, Zhang J, et al. ; Association of age at...
High Grade Glioma			Baker SJ, et al. ; Somatic histone H3 alterations...

Last Updated: Jan 09, 2012

Pediatric Cancer Genome Project | Explore

Number of Patients by Disease

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